No response was observed to the HSP-90 inhibitor AUY-922, or to the PI-3K inhibitors BEZ-235 and GDC-0941, or statins. In contrast, only a minor response was observed to a CDK inhibitor (SNS-032) or the AKT inhibitor perifosine. We found that, in addition to the demonstrated single agent clinical activity of alkylating agents (melphalan), cortico-steroids (dexamethasone) and proteasome inhibitors (bortezomib and carfilzomib), the histone deacetylase (HDACs) inhibitors vorinistat and panobinostat showed strong anti-myeloma activity, inducing a dramatic reduction of the M-spike after only two weeks of treatment. Response rates were calculated by comparing the M-spike levels after treatment to the levels observed at d0. We have utilized “naïve‘, untreated Vk*MYC mice at early stages of myeloma disease. We have re-evaluated the anti-myeloma activity of novel compounds that have passed extensive pre-clinical characterization and are currently in clinical trials. The M-spike represents a very useful marker to monitor tumor burden by periodic bleeding, as is done in patients. Specifically, the Vk*MYC myeloma is indolent (with a very low proliferative index), confined to the bone marrow, and secretes a monoclonal protein detected by serum protein electrophoresis. The immuno-competent Vk*MYC mouse model of myeloma has already demonstrated high biological fidelity to the human disease, making it a better model to study the behavior of myeloma cells in the context of a native microenvironment. Unfortunately, without a large randomized trial, it is often difficult to interpret the response rates observed in these patients, and determine the contribution of the novel compound to the response observed to the combination treatment. One solution to this problem is to treat patients earlier in the course of their disease, which has been done by using the novel drug in combination with an approved drug. Another reason may be that to be able to test novel compounds, only relapsed and refractory patients are studied, at a stage in their disease that is unlikely to respond to any drug. One reason for that may be an intrinsic inadequacy of pre-clinical models to predict activity, since for the most part they do not represent the complexity of human MM in an endogenous micro-environment. With the increasing availability of novel compounds, a number of drugs that have shown promising anti-myeloma activity in extensive pre-clinical studies failed to demonstrate clear efficacy in subsequent clinical trials.
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This cooldown is also in place at the beginning of a game, meaning you have 10 seconds to kill a hunt before they run away. Every 11 seconds you can herd a hunt, this means the hunt will run in the direction your villager took. Split your vills on food crates for this and only start the other crates and herding when the first villager is in queue.Ģ. Get the first vill in the queue at 0:08 gametime. Always have vills in the queue vills=eco=army=win. Macro is the big-picture management of your economy, in essence good macro means having the right resources at the right time and having lots of them.ġ. If you're switching from RE or EP, take a look at the DE balance change list from RE patch. Not Decided yet? As of now (October 2020) the good civs in my opinion are Sweden, Ottoman, British, France, Germany and Spain. For example, I use Brits and Germans as secondary civs to my main French. To mix things up or to play in a tournament setting, you need a 2nd and 3rd civilization, here it is easiest to go with civs similar to your main. This gives easy wins, but no learning experience. Other civilizations can, especially against weaker players, often get away with one "bot"-build in every matchup. If you win as France, you most likely outplayed your opponent. As France, both these strats work less well, so you have to work more on your decision making, adaption skills, timing, micro, macro and strategy. Every other civilization has some innate wincondition, where you can just do one thing and win (either boom or rush mindlessly). If you are playing quicksearch (which I recommend), this is a good civilization to do so with, since you will never be in a hopeless battle.Ģ. It has good matchups across the board and performs decently on every map. There are two main reasons for choosing France:ġ. I recommend France for this, because it is a Euro civ and the most straight-forward to play, but you can really chose any civ you like. Practicing with one civilization eliminates a lot of cognitive load and lets you focus on improving more suddle things like managing economy well and executing fast, instead of having to think about more trivial things like the strategy and units you want. Conclusion/ How to improve/ Where to startįirst you must choose a civilization, I recommend sticking to one main. I will not present specific build orders, this guide is about more general concepts.ħ. I will explain everything a good player knows and does to win the game. I will assume you have rudimentary knowledge of the game (which, since you are on this site, you most definitely have), meaning you know what villagers, military, housing, production, technology and xp do. I reached Top100 Elo and even though I am not a top player, I know the basics which I now want to share with you. This is a comprehensive guide that will tell you everything you need to know to play this game well. Originally written for the ESOC 2020 Winter Championship, I overhauled it for DE. How to play well in the AoE III Definitive Edition! I do agree with you that what makes a game unique is the gameplay and story itself but you can't underestimate a potential player's first impression. So, I personally would not use it as my graphic style for a commercial project because, visually, it would look too alike to a plethora of other games. For example, though Time Fantasy is an excellent style and a definitely nice change of pace, I believe it's the most commonly used art below Character Generator stuff. I believe it all depends on literally how common the graphic style is used. I think recently some sideview battler packs came out for that as well.įirst Seed stuff is nice because it is a notch higher in realism and the doors allow for two block high characters (So if you edit your own, you dont have to edit all the doors of the DLC too.)īut I only know of the Town of Beginnings and Wood and Cave DLC in that genre. ( Some assetts I have seen on itch.io that are not on steam store. I would suggest the time fantasy characters for a more "Chrono Trigger" type look, plus there are a lot of DLCs for that so theme continuance is very possible. I suppose one could remaster their sprites into something amazing but are you going to overhaul the maps and battle system to reflect that new level of realism too? It is a lot of work to just customize the tilesets and to comission outside sources to do it for you can add up as well. I do concur that the sprites do not look menacing even when it is a dark knight because of their tiny size, but I always assume that to be the sterotype placeholder image for RPG games. When I see the typical 4 party vs unknown evil I don't care at that point about customized graphics - it sounds cookie cutter to all the ones out there already. Does it depend on each particular game's tone to determine whether the character generator graphics will work? Feel free to share.Ī problem with relying on any outside sourced DLC is that when eveyone uses that, then how is your game unique then? I think to keep your game unique, one should focus on your story or a game mechanic off the beaten path. Do you disagree with my ramblings? Do you like the look of the chibi's? Do you think that they can be taken seriously? Should more people use the DLC's that add custom sprites, portraits, and even busts? (Ex. I just wanted to get other people's opinions on this, since so many of us that use the Engine use the Character Generator to handle all their sprites. I now go out of my way to find and buy/download custom graphics and even edit them to be taller and larger (Which, is a VERY ANNOYING process but one that I personally think is worth it) so that my game can actually be taken seriously. It's just so hard to take a dramatic moment in the game seriously when everyone's 2 feet tall.Īfter playing through a ton of other RPG Maker games that use them (A whole lot of commercial ones at that), I quickly realized that (IMO) in order to actually get your game to stand-out, you need to have graphics that are not from the base RPG Engine at all, even from the character generator at all. Not to mention, there's no option to make busts in the character generator.Īs for the chibi's themselves, I have to say I hate them. RTP graphics but, after awhile, they all start to blend together and they all scream RPG Maker. Sure, everyone's created characters are different and they are definitely better than the but, at the end of the day, are they really that great? Are they even custom? At this point, I have to say no. Heck, there's even a whole ton of DLC and free resources to add more parts to the generator. A simple way to make "unique" graphics for your game. So, the character generator for the engine is pretty cool, at first glance. Explore all the different branches of modelling!.And how rewarding is it to have your sim love their job? Compare that to being a tech guru (barf!). You’d also get to explore different branches of modelling from a billboard model to a fashion model. Your beautiful sim can get hired by industries to show off the looks that YOU provided for them! This career starts off at a low pay, but in the end, the hard work is worth it because you can have your sim pull off crazy fashion looks, attend photoshoots, and gain fame. Hate to break it to you buddy, but not all of us can pull off a modeling career in the real world.īUT, if you’re into fashion and love customizing your sims, aka downloading custom content for hair, makeup, clothes, (guilty as charged), the modelling career is perfect for your sim. You’d dedicate your sims life to doing what they love!.Here’s why your sim should be a youtuber: To post videos of you doing what you love? Who wouldn’t want that? If you missed out on the opportunity in the real world, why not live your dream through your sim? Your sim can be a cook, a vlogger, makeup artist, or a gamer! There’s no way we all haven’t imagined what it would be like to be a youtuber and not completely gag at the idea. Though starting off at a low pay, this may be one of the funnest mods you could install for your sim. No? Just me? At some point, we all fall guilty to scrolling mindlessly through every ASMR video, DIY’s, How to’s, Makeup Tutorials, Vlogs from our favorite Youtubers, you name it!Īnd your sim can be one with the Youtuber mod! Image PropertiesIf you're a sucker for mukbangs like these guys are, being an youtube influencer in the sims sounds like a dream.īut okay, let’s admit it, youtube is our life. Easy money, and no more waiting to level up!.200 simoleons an hour = easy route to being a billionaire.Well, why put in all that work when you can get twice as much money being a scammer? And fast-forwarding time just doesn’t seem like it’s enough. It’s exhausting to have your sims work for careers that need Level 10 in Writing, Level 8 in Debate, Level 9 in Logic… bla, bla, bla… just to get the big bucks. Patience is key when it comes to leveling up your sim for their career. This could be your sim with the scammer mod, where your sim will get the opportunity to attain the money they've always wanted. And scamming people gets to be the fun little bonus! Are your sims desperate for new ways to make money? Whether they’re in a financial crisis or simply looking for a new passion, this article is for you! Find and download mods that will fulfill your sim’s dreams of making big bucks or living their dream life! 10. Requires the General Pie menus and Ilkavelle's Realistic Swimming mod. Ī semi-active career for adventurous Sims. Required Packs: City Living (for the career)Īn EA career and writing process overhaul. Enhanced by other Packs.Ī semi-active career with only six levels loosely inspired by the CL Critic career with a travel-focused twist. Required Packs: City Living and Get Famous. Requires the General Pie menus and the Mood Pack. Requires the General Pie menus and Shared Library.Ī semi-active for Sim influencers. This mod is inspired by Sims 2 Pet Careers. Required Packs: Get to Work, City Living, Get Famous, University Life, Paranormal Stuff, Realm of Magic.Ĭareers fit for your furry friends. Ī semi-active career for those who dabble in the paranormal. Required Packs: Jungle Adventures, Get to Work, City Living, Island Living, University Life, Get Famous, and Snowy Escape. Download here / alternate Requires the General Pie menus and Frankk's Language Barriers. Required Packs: City Living and Paranormal Stuff.Ī semi-active career focusing on language, charisma, and more. Required Packs: Get to Work, City Living, and Cottage Living.Ī non-traditional, semi-active career for those Sims who ain't afraid of no ghosts. Enhanced by other Packs.Ī new Freelance career for those who dabble in the culinary arts. Required Packs: Discover University (for the career)Īn overhaul of the base game Entertainer Career. Requires the General Pie menus and Shared Tuning. Requires the General Pie menus.Īn overhaul of the DU Education Career. These are mods which add new careers or modify existing careers for the Sims 4.įlexible babysitting gigs for teens and university students. Released, 'Bhaag Milkha Bhaag' stars Farhan Akhtar, Sonam Kapoor, Divya Dutta, Pavan Malhotra The movie has a runtime of about 3 hr 6 min, and received a user score of 74 (out of 100) on TMDb, which collated reviews from 234 knowledgeable users. Now, before we get into the nitty-gritty of how you can watch 'Bhaag Milkha Bhaag' right now, here are some details about the Viacom18 Studios history flick. We've listed a number of streaming and cable services - including rental, purchase, and subscription choices - along with the availability of 'Bhaag Milkha Bhaag' on each platform when they are available. It just maybe worth it.Want to behold the glory that is ' Bhaag Milkha Bhaag' on your TV, phone, or tablet? Discovering a streaming service to buy, rent, download, or watch the Rakeysh Omprakash Mehra-directed movie via subscription can be difficult, so we here at Moviefone want to help you out. Shankar-Ehsaan-Loy bring Prasoon Joshi's lyrics to life with their music. The first half could have been tightened but perhaps the filmmaker's stubbornness becomes evident.Įven songs like Maston ka Jhund and the title track power the film but some songs could have been snipped. Milkha overcomes this fear in a race in Pakistan. But here amid the noise of that evening, he turns around and loses.īut life does not end at the loss. Then comes the drive, which he lives with and four years later, he reaches 1960 Rome Olympics after winning the Asiad and Commonwealth Games among many other championships, and all eyes are on him. He understands that the race is not as simple as it seems. This race comes to an important turn in the 1956 Melbourne Olympics, where he is unable to survive in the first round of the 400m sprint. First for the greed of an extra glass of milk and escaping parade, then to wear the India blazer and subsequently to have the world at his feet for running. Here, he falls for Bira, who lives in a refugee colony in Shahdara and makes up his mind to win her, and is enlisted. He moves to Delhi after Partition with his sister. The flashback of the story shows a Sikh boy growing up in Multan. Prasoon Joshi's script keeps a close grip on the emotion of the story.įarhan Akhtar's acting could leave one rejoicing. Rakeysh Omprakash Mehra is the same director who gave us Rang de Basanti and comes across as the director who livens up every moment. His friend's son asks him if he is the same Milkha who runs.īhaag Milkha Bhaag is the story of that same 'Flying Sikh' Milkha Singh but is bogged by detail in the first half. The tragedy ends in Pakistan when his friend tells him that it's not people but circumstances that are bad. Later on in the film, Milkha slips yet again at an important moment when the massacre in Pakistan forces him to turn around. The kid screams and runs to the corpses but slips on the bloodied floor. Scene 2: Some time later, the kid returns to his gutted yet wet house to find the bodies of his parents and the rest of the family. The boy's father screams, run Milkha run. The boy is a Sikh in the newly-carved Islamic republic and his village is under attack by Pathans. Scene 1: The sun is setting, it's raining and a boy is running in what is pictured as Pakistan. Mean squaresĮach mean square value is computed by dividing a sum-of-squares value by the corresponding degrees of freedom. They say "B x S/A" where Prism says "residual", and say "S/A" where Prism says "subject". Table 12.16 on page 595 explains the ANOVA table for two way ANOVA with repeated measures in one factor. But note they use the term "A x B x S" where Prism says "Residual". Table 12.2 on page 576 explains the ANOVA table for repeated measures in both factors. When there are repeated measures for both factors, this value equals the number of subjects (3) minus 1, so df=2.ĭetails on how the SS and DF are computed can be found in Maxwell and Delaney (1). When the matched values are in the same row, there arr 6 subjects treated in two ways (one for each row), so df is 4. When the matched values are stacked, there are 9 subjects and three treatments, so df equals 6. The df for subjects is the number of subjects minus number of treatments.It is the same regardless of repeated measures. The df for the systematic differences among columns equals number of columns -1, whiich is 2 for this example.This is the same regardless of repeated measures. The df for the systematic differences among rows equals number of rows -1, which is 1 for this example.The df for interaction equals (Number of columns - 1) (Number of rows - 1), so for this example is 2*1=2.It is the same regardless of any assumptions about repeated measures. This is the total number of values (18) minus 1. In the final columns, some of that variation can also be attributed to interaction between subjects and either rows or columns. The SS for residual is smaller when you assume repeated measures, as some of that variation can be attributed to variation among subjects.The SS values for the interaction and for the systematic effects of rows and columns (the top three rows) are the same in all four analyses.This measures the total variation among the 18 values. Now look at the SS columns for the analyses of the same data but with various assumptions about repeated measures. The last row shows the total amount of variation among all 18 values.The second to the last row shows the variation not explained by any of the other rows.The third row show the the amount of variation that is due to systematic differences between the columns.The second row show the the amount of variation that is due to systematic differences between the two rows.Equivalently, it quantifies how much variation is due to the fact that the differences among columns is not the same for both rows. It quantifies how much variation is due to the fact that the differences between rows are not the same for all columns. The first row shows the interaction of rows and columns.I rearranged and renamed a bit so the four can be shown on one table.įocus first on the sum-of-squares (SS) column with no repeated measures: The values below are all reported by Prism. The table below shows the ANOVA tables for the four analyses. The colors are repeated between tables, but this means nothing. Each color within a table represents one subject. The tables below are color coded to explain these designs. I analyzed the data four ways: assuming no repeated measures, assuming repeated measures with matched values stacked, assuming repeated measures with matched values spread across a row, and with repeated measures in both directions. There were no missing values, so 18 values were entered in all. To create the examples below, I entered data with two rows, three columns, and three side-by-side replicates per cell. But what happens when you have chosen a default signature? There are other ways through which you can achieve the same results, but the steps given above are some of the simplest. That’s how to set a default email signature in Outlook 365.
The Cafeteria is the location where Lunch occurs. Spending 2 apples in this room will kill the player, due to it being filled with a mysterious gas. This room also contains a vat filled with a mysterious green substance that goes into the kitchen. It contains tools like shovels, to weapons like axes and chainsaws. This area is almost always locked to access this room, the player must receive the key during certain quests. The Janitor's Closet, known by The Janitor by the weapons closet, is located in the boy's bathroom. The Janitor is usually seen here during Morning Time. The Boy's Bathroom is one of the two bathrooms located at the school. Applegate, who tells the students to play with the basketball or dodgeball. Those who do not pay go to gym class instead. If the player is in the playground when recess ends, the player has the choice to pay the $3.00 lab fee to go to science class. Danner, any students in Study Hall are forbidden from speaking or moving, and any student who does so will be killed. By default, Buggs will always be located here during recess. Those who violate school rules during Morning Time or are caught with contraband are sent here instead of recess. This classroom is also the location of Study Hall. Applegate, who, due to her withdrawal, tells her students to simply play and leave her alone. This classroom features cubbies and a toy box and is taught by Ms. By default, the player is sent here, but can earn his way to the "Smart Class" by completing the Flowers for Diana mission and bringing the A+ to school. The "Dumb" class is where all the "Dumb" children go for Morning Time. Locations First Floor "Dumb" Class/Study Hall +: This character returned from the previous game, Kindergarten. ': This character makes no physical appearance and is only mentioned. *: This character has no associated mission.
Sweet BBQ pork chops: Combine celery salt, BBQ sauce, honey, garlic powder and paprika to a glaze.īreaded pork chops: Coat the pork chops with flour, egg and breadcrumbs.īuffalo pork chops: Coat the chops in buffalo sauce. Here are some options:Ĭilantro lime pork chops: Marinate the pork chops with lime juice and fresh cilantro. You can add these based on personal preferences. I typically cook mine either with seasoning, or a glaze. I prefer to use boneless pork loin steks, but any pork chops will work.If possible, leave the meat to marinate in the seasoning for a while before cooking. Don't forget the seasoning! Use any glaze, spices or sauces that you like - at least salt and pepper.Use a meat thermometer to be sure, as the cooking time will vary depending on what air fryer you use or how thick the pork chops are. Cooking them for just the right amount of time is key.Here's my best advice on how to make perfect air fryer pork chops: Use a meat thermometer to check the temperature.Īlso, be careful not to overcook the pork, as this causes the meat to dry out. You should remove the pork chops from th air fryer when the middle part of the pork chops has reached 145☏/63☌. Pork has to be completely cooked through to be considered safe to eat. As they are larger, they also often require more seasoning or glaze to coat completely. In general, larger, thicker, bone-in pork chops will take longer to cook through compared to thin boneless pork chop fillets. Keep in mind that certain things might impact the cooking time or amount of seasoning required. You can use any type of pork chops for this recipe. Depending on the size of the pork chops, this usually takes 8-12 minutes. They are done when they have reached an internal temperature of 145☏/63☌. If you have a smaller air fryer, you might have to fry them in several batches.Īir fry the pork chops until they start to turn golden, then flip and cook on the other side. Add the pork chops, and make sure to leave some space between each chop. If possible, you can leave the pork chops to marinade in the sauce for up to 8 hours. □ InstructionsĬoat the pork chops on both sides with the glaze. For this you will need BBQ sauce, honey, garlic powder, celery salt and paprika powder. You can choose exactly which seasoning to use, but I suggest making a sweet honey BBQ glaze. You also want to use some sort of seasoning, marinade, glaze or sauce with the pork chops. □ IngredientsĪll you need to cook pork chops in the air fryer, is just pork chops and an air fryer. The air fryer is a quick and easy way to prepare pork chops, and no grease is required! Make sure also check out our complete air fryer archive for more recipe inspiration. It gives the food a fried-like texture, without using any oil or grease. An air fryer is a kitchen appliance which uses air pressure to cook food. Pork chops are absolutely fantastic when cooked in the air fryer. Read more about it in the privacy policy. This recipe is absolutely perfect for a quick and easy weeknight meal. These air fryer pork chops are juicy, tender and made in 15 minutes. Click the Hardware properties > Under the WiFi properties, click the Edit button next to the IP assignment. Go to Settings > Select the Network & internet > Turn on the WiFi tab on the right panel. Apply these steps to edit the IP address. You need to ensure your devices are under the same network. How to Transfer File between Two Computers Using Wi-Fi: If you want to send some small files to another PC, I will recommend the WiFi option. Select the targeted device and start to transfer files. The phone/PC name should be shown on the list. If you have turned on the WiFi Direct of another device. Click the "Add Bluetooth or other devices". Go to Devices > Click the "Bluetooth and other devices". Click the Windows icon and select Settings. How to Set Up WiFi Direct on Windows 10/11: How to Send Files via WiFi Direct from PC to PC If the Microsoft Wi-Fi Direct Virtual Adapter is not included, unfortunately, your PC does not support WiFi Direct connection. Then you can see all Wireless LAN adapters here. Type the command line and press Enter button to execute: ipconfig /all When you see the Windows PowerShell, right-click it and click "Run as Administrator". Click the search icon from the taskbar and type PowerShell on it. If not supported, please move to the easier method part and do file transfer quickly. Is WiFi Direct Compatible with My ComputerĪlthough Microsoft has supported WiFi Direct since Windows 8, it's better to follow the below steps to check whether WiFi Direct is available on your device. WiFi Direct can directly work between devices, like PC to Phone/Printer, Phone to PC, etc. WiFi Direct: No need for routers and WiFi. WiFi: With the Internet, you can use WiFi to share files (not too big) from one computer to another computer. What is the difference between WiFi and WiFi-Direct: Compared to traditional Wi-Fi, it can transfer large files, connect printers and etc. Wi-Fi Direct is an offline way to direct connect computers or smartphones to each other. Tap Settings on your device and select the WiFi option Step 2. Transfer Files from Phone to PC Wireless Without Internet Choose "PC to PC" to go to the next step. Open EaseUS Todo PCTrans on both of your computers. Set Up WiFi Direct on Windows 10/11 Transfer File between Two Computers Using Wi-Fi. |
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